Research Interest: Cytokine based Immunotherapies to treat lymphopenia, Clinical biomarkers in psychological disorders, Effects of Inflammation on hematopoiesis.

Research Interest: A specialist in pediatrics and epidemiology.

Research Interest: Bacteria of the genus Staphylococcus, in particular the species S. aureus and virulence factors produced by this species. In the so far carried out research, the results of which were published in several peer-reviewed journals I analyzed:

1.The influence of leucocytotoxic and superantygenic virulence factors produced by S. aureus strains isolated from milk of cows with mastitis on the cytokine production and gene expression in bovine leukocyte cultures in vitro;
2. the impact of staphylococcal exotoxins on the process of phagocytosis in vitro;
3. the efficacy of treatment of mastitis by staphylococcal autovaccine;
4. the profile of resistance to methicillin of coagulase-negative staphylococci isolated from animals;
5. the profile of the genes encoding superantigens in S. aureus and S. xylosus isolates collected from cows;
6. the possibility of transfer of genes encoding superantigens between staphylococci occurring in the same mammary gland;
7. genetic relatedness of staphylococci isolated within a herd of animals;
8. the biological activity of staphylococcal exosecretions against leukocytes in vitro;
9. the impact of staphylococcal virulence factors on the morphology of leukocytes in vitro.
I also analyzed and published in the GenBank several new 16S rRNA gene sequences of bacteria representing different species of staphylococci, identified by PCR-RFLP analysis of gap gene. Furthermore, as a contributor I published in the GenBank the 16S rRNA gene sequences of bacterial isolates, which were unidentified based on the polymorphism of gap gene, of which at least two isolates represent new species or subspecies of the staphylococci.
The second direction of my research concerns the use of magnetic fields, in particular the rotating magnetic field to modify the functional parameters and pathogenicity potential of different species of microorganisms. At the present, I’m analyzing the influence of magnetic field on metabolic processes in microorganisms, both at the cellular and molecular level. As a continuation of my first research mainstream microorganism used in these studies is primarily S. aureus.

Research Interest: Immune based inflammatory disorders (with special reference to nanomedicines).

Research Interest: Virus and host interaction, signal transduction, vaccine development, biotechnology.

Research Interest: Infectious disease, vaccine, immunology, focus in infectious diseases, epidemiology, microbiology, vaccine development and efficacy.

Research Interest: Endocrine and metabolic diseases in prostate cancer, bone metabolism, renal function, and immune structure in prostate cancer.

Research Interest: Antigen processing and presentation, relating to the understanding of these processes and manipulation of them in order to treat.

Research Interest: Molecular mechanisms of immune evasion of EBV and HSV-1. Molecular mechanisms of EBV and HSV-1 infection and its interaction with the host. Mechanisms of pathogenesis of EBV and HSV-1 infection.

Published Papers:

1.    Representative papers published after work

1)    Li ML, Chen T, Wang P, Zou XM, Xu Z, Wang YF, Chen DX, Peng T, Cai MS(*). Characterization of the nucleocytoplasmic transport mechanisms of Epstein-Barr virus BFLF2. Cellular Physiology and Biochemistry, 2018, Accept. (SCI, IF=5.5)

2)    Cai MS, Liao ZM, Chen T, Wang P, Zou XM, Wang YF, Xu Z, Jiang S, Huang JL, Chen DX, Peng T, Hong GD, Li ML(*). Characterization of the subcellular localization of Epstein-Barr virus encoded proteins in live cells. Oncotarget, 2017, 8(41), 70006-70034. (SCI, IF=5.168)

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=19549&author-preview=f31

3)    Cai MS, Li ML, Wang KZ, Wang S, Lu Q, Yan JH, Mossman KL, Lin RT, Zheng CF(*). The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway. Plos One, 2013, 8(1), e54586. (SCI, IF=3.534)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054586

4)    Cai MS, Deng SX, Li ML(*). Comparison of the immune responses in BALB/c Mice following immunization with DNA-based and live attenuated vaccines delivered via different routes. Vaccine, 2013, 31(9),1353-1356. (SCI, IF=3.485)
https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(12)01308-4

5)    Cai MS, Jiang S, Zeng ZC, Li XW, Mo CC, Yang YJ, Chen CK, Xie PP, Bian Y, Wang JL, Huang JL, Chen DX, Peng T, Li ML(*). Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22. Cell & Bioscience, 2016, 6: 3. (SCI, IF=3.294)
https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-016-0069-7

6)    Cai MS, Jiang S, Li XW, Zeng ZC, Li ML(*). Characterization of the nuclear import mechanisms of HSV-1 UL31. Biological Chemistry. 2016, 397(6): 555-561. (SCI, IF=3.273)
https://www.degruyter.com/doi/10.1515/hsz-2015-0299

7)    Cai MS, Huang ZB, Liao ZM, Chen T, Wang P, Jiang S, Chen DX, Peng T, Bian Y, Hong GD, Yang H, Zeng ZC, Li XW, Li ML(*). Characterization of the subcellular localization and nuclear import molecular mechanisms of herpes simplex virus 1 UL2. Biological Chemistry. 2017, 398(4): 509-517. (SCI, IF=3.273)
https://www.degruyter.com/doi/10.1515/hsz-2016-0268 

8)    Cai MS, Li ML, Zheng CF(*). Herpesviral infection and Toll-like receptor 2. Protein & Cell, 2012, 3(8), 590-601. (SCI, IF=3.22)

https://dx.doi.org/10.1007/s13238-012-2059-9

9)    Li ML, Jiang S, Mo CC, Wang JL, Huang JL, Zeng ZC, Li XW, Chen CK, Yang YJ, Peng T, Cai MS(*). Identification of molecular determinants for the nuclear import of pseudorabies virus UL31. Archives of Biochemistry and Biophysics, 2015, 587, 12-7. (SCI, IF=2.807)
https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(15)30075-8

10)    Li ML, Jiang S, Wang JL, Mo CC, Zeng ZC, Yang YJ, Chen CK, Li XW, Cui W, Huang JL, Peng T, Cai MS(*). Characterization of the nuclear import and export signals of pseudorabies virus UL31. Archives of Virology, 2015, 160, 2591-2594. (SCI, IF=2.255)
https://link.springer.com/article/10.1007/s00705-015-2527-7

11)    Cai MS, Chen DX, Zeng ZC, Yang H, Jiang S, Li XW, Mai JY, Peng T, Li ML*. Characterization of the nuclear import signal of herpes simplex virus 1 UL31. Archives of Virology, 2016, 161(9):2379-2385. (SCI, IF=2.058)
https://dx.doi.org/10.1007/s00705-016-2910-z

12)    Li ML, Cui W, Mo CC, Wang JL, Zhao ZY, Cai MS(*). Cloning, expression, purification, antiserum preparation and its characteristics of the truncated UL6 protein of herpes simplex virus 1. Molecular Biology Reports, 2014, 41(9), 5997-6002. (SCI, IF=2.024)
https://dx.doi.org/10.1007/s11033-014-3477-y

2.    Representative papers published at the time of Ph.D. candidate
13)    Cai MS, Wang S, Long J, Zheng CF(*). Probing of the nuclear import and export signals and subcellular transport mechanism of varicella-zoster virus tegument protein open reading frame 10. Medical Microbiology and Immunology, 2012, 201(1), 103-111. (SCI, IF=3.545)
https://link.springer.com/article/10.1007/s00430-011-0211-4

14)    Cai MS, Wang S, Xing JJ, Zheng CF(*). Characterization of the nuclear import and export signals, and subcellular transport mechanism of varicella-zoster virus ORF9. Journal of General Virology, 2011, 92(Pt 3), 621-626. (SCI, IF=3.363)
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.027029-0#tab2

15)    Li ML, Wang S, Cai MS, Zheng CF(*). Identification of nuclear and nucleolar localization signals of PRV early protein UL54 reveals that its nuclear targeting is required for efficient production of virus. Journal of virology, 2011, 85, 10239–10251. (SCI, IF=5.402)
http://jvi.asm.org/content/85/19/10239.long

16)    Wang L, Li ML, Cai MS, Xing JJ, Wang S, Zheng CF(*). A PY-nuclear localization signal is required for nuclear accumulation of HCMV UL79 protein. Medical Microbiology and Immunology, 2012, 201(3),381-387. (SCI, IF=3.545)

https://link.springer.com/article/10.1007/s00430-012-0243-4

17)    Li ML, Wang S, Cai MS, Guo H, Zheng CF(*). Characterization of molecular determinants for nucleocytoplasmic shuttling of PRV UL54. Virology, 2011, 417, 385-417. (SCI, IF=3.351)
https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(11)00268-6

3.    Representative papers published at the time of M.Sc. candidate
18)    Cai MS, Cheng AC(*), Wang MS, Chen WP, Zhang X, Zheng SX, Pu Y, Lou KP, Zhang Y, Sun L, Wang LL, Zhu DK, Luo QH, Chen XY. Characterization of the duck plague virus UL35 gene. Intervirology, 2010, 53(6), 408-416. (SCI, IF=1.756)
https://www.karger.com/?DOI=10.1159/000317291

19)    Cai MS, Cheng AC (*), Wang MS, Zhao LC, Zhu DK, Luo QH, Liu F, Chen XY. His6-tagged UL35 protein of duck plague virus: expression, purification, and production of polyclonal antibody. Intervirology, 2009, 52(3),141-151. (SCI, IF=1.106)
https://www.karger.com/?DOI=10.1159/000221833

20)    Cai MS, Cheng AC (*), Wang MS, Zhao LC, Zhu DK, Luo QH, Liu F, Chen XY. Characterization of synonymous codon usage bias in the duck plague virus UL35 gene. Intervirology, 2009, 52(5), 266-278. (SCI, IF=1.106)
https://www.karger.com/Article/Abstract/231992

Research Interest: The structure of sulfated polysaccharides extracts from seaweeds. The activity of sulfated polysaccharides such as nephrophaty and Parkinsion Disease. The comprehensive utilization of seaweeds especially Saccharina japonica.

Research Interest: Nanoparticles, liposomes, solid lipid naonparticles, and anhydrous reverse micelles, drug/vaccine carriers, freeze-drying of pharmaceutics, design, carrying out and analysis of in vivo tests, separation and purification of chemicals, extraction and analysis of therapeutic.

Research Interest: Protein Engineering, Adjuvant and Vaccine Delivery Systems, Vaccinology, cGMP Quality Management, Immunology.

Research Interest: My Research Focus on Design Universal and Live Attenuated Influenza Vaccine by using Novel Methods, and Testingthese New Generation Vaccine Candidates in Humanized Mice and Ferrets. As Well, We would like to explore the Mechanism of Cross-Protection induced by live Attenuated Influenza against seasonal and Pandemic Influenza Viruses. Our Results Suggested That Activation of T cell Is Crucial for the cross Protection Stimulated By vaccination With Live Attenuated Influenza Vaccine. In Future Research, We Will Focus on B Cell Development Stimulated by Vaccination with Live Attenuated Influenza vaccine. To Facilitate The Development Of More Effective Vaccines, We Are Also Researching: The Effect Of Current Vaccination Programs On The Epidemiological Changes Of Respiratory Pathogens (Strain Replacement And Antigenic Variation); How People Respond To Infections Or Vaccinations At The Cellular And Molecular Levels (B Cell, T Cell, And Gene expression Levels) identification of New Protective Antigens Through Genomic And Proteomic Approaches.

Research Interest: Nanomedicine, Controlled/Targeted Drug Delivery, Toxicology, Pharmacology, Cellular Interaction, Nanofilms and Microcapsules, Biomimetic, Microbiology, Immunology.