Research Interest: My Research Focus on Design Universal and Live Attenuated Influenza Vaccine by using Novel Methods, and Testingthese New Generation Vaccine Candidates in Humanized Mice and Ferrets. As Well, We would like to explore the Mechanism of Cross-Protection induced by live Attenuated Influenza against seasonal and Pandemic Influenza Viruses. Our Results Suggested That Activation of T cell Is Crucial for the cross Protection Stimulated By vaccination With Live Attenuated Influenza Vaccine. In Future Research, We Will Focus on B Cell Development Stimulated by Vaccination with Live Attenuated Influenza vaccine. To Facilitate The Development Of More Effective Vaccines, We Are Also Researching: The Effect Of Current Vaccination Programs On The Epidemiological Changes Of Respiratory Pathogens (Strain Replacement And Antigenic Variation); How People Respond To Infections Or Vaccinations At The Cellular And Molecular Levels (B Cell, T Cell, And Gene expression Levels) identification of New Protective Antigens Through Genomic And Proteomic Approaches.

Research Interest: Nanoparticles, liposomes, solid lipid naonparticles, and anhydrous reverse micelles, drug/vaccine carriers, freeze-drying of pharmaceutics, design, carrying out and analysis of in vivo tests, separation and purification of chemicals, extraction and analysis of therapeutic.

Research Interest: Her project here focused on the development of a novel therapeutics for the treatment of immune and inflammatory skin diseases such as psoriasis using a skin epidermal Langerhans cell model.

Research Interest: Molecular epidemiology, Development of diagnostic tests for viral disease, Cell culture, Bioinformatics.

Research Interest: Interest has been in the field of immunology.

Research Interest: Immunology, veterinary immunology, lymphocytes, innate immunity, receptors, viral infections, RNA viruses.

Research Interest: Antigen processing and presentation, relating to the understanding of these processes and manipulation of them in order to treat.

Research Interest: Biotechnology, Vaccines, Vaccine Development, Virology, Viral Vaccines.

Research Interest: Pathogenesis and Treatment of Melanoma, and in Part are directed at Developing Tools to Study Melanoma.

Research Interest: Molecular mechanisms of immune evasion of EBV and HSV-1. Molecular mechanisms of EBV and HSV-1 infection and its interaction with the host. Mechanisms of pathogenesis of EBV and HSV-1 infection.

Published Papers:

1.    Representative papers published after work

1)    Li ML, Chen T, Wang P, Zou XM, Xu Z, Wang YF, Chen DX, Peng T, Cai MS(*). Characterization of the nucleocytoplasmic transport mechanisms of Epstein-Barr virus BFLF2. Cellular Physiology and Biochemistry, 2018, Accept. (SCI, IF=5.5)

2)    Cai MS, Liao ZM, Chen T, Wang P, Zou XM, Wang YF, Xu Z, Jiang S, Huang JL, Chen DX, Peng T, Hong GD, Li ML(*). Characterization of the subcellular localization of Epstein-Barr virus encoded proteins in live cells. Oncotarget, 2017, 8(41), 70006-70034. (SCI, IF=5.168)

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=19549&author-preview=f31

3)    Cai MS, Li ML, Wang KZ, Wang S, Lu Q, Yan JH, Mossman KL, Lin RT, Zheng CF(*). The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway. Plos One, 2013, 8(1), e54586. (SCI, IF=3.534)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054586

4)    Cai MS, Deng SX, Li ML(*). Comparison of the immune responses in BALB/c Mice following immunization with DNA-based and live attenuated vaccines delivered via different routes. Vaccine, 2013, 31(9),1353-1356. (SCI, IF=3.485)
https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(12)01308-4

5)    Cai MS, Jiang S, Zeng ZC, Li XW, Mo CC, Yang YJ, Chen CK, Xie PP, Bian Y, Wang JL, Huang JL, Chen DX, Peng T, Li ML(*). Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22. Cell & Bioscience, 2016, 6: 3. (SCI, IF=3.294)
https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-016-0069-7

6)    Cai MS, Jiang S, Li XW, Zeng ZC, Li ML(*). Characterization of the nuclear import mechanisms of HSV-1 UL31. Biological Chemistry. 2016, 397(6): 555-561. (SCI, IF=3.273)
https://www.degruyter.com/doi/10.1515/hsz-2015-0299

7)    Cai MS, Huang ZB, Liao ZM, Chen T, Wang P, Jiang S, Chen DX, Peng T, Bian Y, Hong GD, Yang H, Zeng ZC, Li XW, Li ML(*). Characterization of the subcellular localization and nuclear import molecular mechanisms of herpes simplex virus 1 UL2. Biological Chemistry. 2017, 398(4): 509-517. (SCI, IF=3.273)
https://www.degruyter.com/doi/10.1515/hsz-2016-0268 

8)    Cai MS, Li ML, Zheng CF(*). Herpesviral infection and Toll-like receptor 2. Protein & Cell, 2012, 3(8), 590-601. (SCI, IF=3.22)

https://dx.doi.org/10.1007/s13238-012-2059-9

9)    Li ML, Jiang S, Mo CC, Wang JL, Huang JL, Zeng ZC, Li XW, Chen CK, Yang YJ, Peng T, Cai MS(*). Identification of molecular determinants for the nuclear import of pseudorabies virus UL31. Archives of Biochemistry and Biophysics, 2015, 587, 12-7. (SCI, IF=2.807)
https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(15)30075-8

10)    Li ML, Jiang S, Wang JL, Mo CC, Zeng ZC, Yang YJ, Chen CK, Li XW, Cui W, Huang JL, Peng T, Cai MS(*). Characterization of the nuclear import and export signals of pseudorabies virus UL31. Archives of Virology, 2015, 160, 2591-2594. (SCI, IF=2.255)
https://link.springer.com/article/10.1007/s00705-015-2527-7

11)    Cai MS, Chen DX, Zeng ZC, Yang H, Jiang S, Li XW, Mai JY, Peng T, Li ML*. Characterization of the nuclear import signal of herpes simplex virus 1 UL31. Archives of Virology, 2016, 161(9):2379-2385. (SCI, IF=2.058)
https://dx.doi.org/10.1007/s00705-016-2910-z

12)    Li ML, Cui W, Mo CC, Wang JL, Zhao ZY, Cai MS(*). Cloning, expression, purification, antiserum preparation and its characteristics of the truncated UL6 protein of herpes simplex virus 1. Molecular Biology Reports, 2014, 41(9), 5997-6002. (SCI, IF=2.024)
https://dx.doi.org/10.1007/s11033-014-3477-y

2.    Representative papers published at the time of Ph.D. candidate
13)    Cai MS, Wang S, Long J, Zheng CF(*). Probing of the nuclear import and export signals and subcellular transport mechanism of varicella-zoster virus tegument protein open reading frame 10. Medical Microbiology and Immunology, 2012, 201(1), 103-111. (SCI, IF=3.545)
https://link.springer.com/article/10.1007/s00430-011-0211-4

14)    Cai MS, Wang S, Xing JJ, Zheng CF(*). Characterization of the nuclear import and export signals, and subcellular transport mechanism of varicella-zoster virus ORF9. Journal of General Virology, 2011, 92(Pt 3), 621-626. (SCI, IF=3.363)
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.027029-0#tab2

15)    Li ML, Wang S, Cai MS, Zheng CF(*). Identification of nuclear and nucleolar localization signals of PRV early protein UL54 reveals that its nuclear targeting is required for efficient production of virus. Journal of virology, 2011, 85, 10239–10251. (SCI, IF=5.402)
http://jvi.asm.org/content/85/19/10239.long

16)    Wang L, Li ML, Cai MS, Xing JJ, Wang S, Zheng CF(*). A PY-nuclear localization signal is required for nuclear accumulation of HCMV UL79 protein. Medical Microbiology and Immunology, 2012, 201(3),381-387. (SCI, IF=3.545)

https://link.springer.com/article/10.1007/s00430-012-0243-4

17)    Li ML, Wang S, Cai MS, Guo H, Zheng CF(*). Characterization of molecular determinants for nucleocytoplasmic shuttling of PRV UL54. Virology, 2011, 417, 385-417. (SCI, IF=3.351)
https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(11)00268-6

3.    Representative papers published at the time of M.Sc. candidate
18)    Cai MS, Cheng AC(*), Wang MS, Chen WP, Zhang X, Zheng SX, Pu Y, Lou KP, Zhang Y, Sun L, Wang LL, Zhu DK, Luo QH, Chen XY. Characterization of the duck plague virus UL35 gene. Intervirology, 2010, 53(6), 408-416. (SCI, IF=1.756)
https://www.karger.com/?DOI=10.1159/000317291

19)    Cai MS, Cheng AC (*), Wang MS, Zhao LC, Zhu DK, Luo QH, Liu F, Chen XY. His6-tagged UL35 protein of duck plague virus: expression, purification, and production of polyclonal antibody. Intervirology, 2009, 52(3),141-151. (SCI, IF=1.106)
https://www.karger.com/?DOI=10.1159/000221833

20)    Cai MS, Cheng AC (*), Wang MS, Zhao LC, Zhu DK, Luo QH, Liu F, Chen XY. Characterization of synonymous codon usage bias in the duck plague virus UL35 gene. Intervirology, 2009, 52(5), 266-278. (SCI, IF=1.106)
https://www.karger.com/Article/Abstract/231992

Research Interest: Diagnosis of fungal infections; Therapy of mycoses; Pathogenesis of fungal infection; Antifungal drug resistance; Fungal infection animal model; Genomics in medical mycology; Candida mucosal immunity; Infectious dermatosis; genodermatoses.

Research Interest: Structural determination of protein-DNA, Solid: X-ray, Solution: 2D & 3D NMR, and Gas: Mass Spectrometry, interactions and their pathways, stability, dynamics, and function.

Research Interest: Immunology, chronic viral infections (hepatitis C virus, Kaposi's sarcoma herps virus), dendritic cells, B cells.

Research Interest: Immune based inflammatory disorders (with special reference to nanomedicines).

Research Interest: Virology/Microbiology, Biochemistry, Clinical Diagnostics, Molecular Biology, Protein Chemistry.