Research Interest: Interest has been in the field of immunology.

Research Interest: Immunology such as Autoimmune Diabetes.

Research Interest: Allergy test in clinical diagnosis, Immunotherapy and in vitro cell assay, Anti-inflammatory properties of natural compounds, Allergy and vaccination, Basophil activation tests.

Research Interest: Cytokine based Immunotherapies to treat lymphopenia, Clinical biomarkers in psychological disorders, Effects of Inflammation on hematopoiesis.

Research Interest: Infectious disease, vaccine, immunology, focus in infectious diseases, epidemiology, microbiology, vaccine development and efficacy.

Research Interest: Nanomedicine, Controlled/Targeted Drug Delivery, Toxicology, Pharmacology, Cellular Interaction, Nanofilms and Microcapsules, Biomimetic, Microbiology, Immunology.

Research Interest: Structural determination of protein-DNA, Solid: X-ray, Solution: 2D & 3D NMR, and Gas: Mass Spectrometry, interactions and their pathways, stability, dynamics, and function.

Research Interest: Oncology, Immunology and Hematopoiesis.

Research Interest: Molecular mechanisms of immune evasion of EBV and HSV-1. Molecular mechanisms of EBV and HSV-1 infection and its interaction with the host. Mechanisms of pathogenesis of EBV and HSV-1 infection.

Published Papers:

1.    Representative papers published after work

1)    Li ML, Chen T, Wang P, Zou XM, Xu Z, Wang YF, Chen DX, Peng T, Cai MS(*). Characterization of the nucleocytoplasmic transport mechanisms of Epstein-Barr virus BFLF2. Cellular Physiology and Biochemistry, 2018, Accept. (SCI, IF=5.5)

2)    Cai MS, Liao ZM, Chen T, Wang P, Zou XM, Wang YF, Xu Z, Jiang S, Huang JL, Chen DX, Peng T, Hong GD, Li ML(*). Characterization of the subcellular localization of Epstein-Barr virus encoded proteins in live cells. Oncotarget, 2017, 8(41), 70006-70034. (SCI, IF=5.168)

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=19549&author-preview=f31

3)    Cai MS, Li ML, Wang KZ, Wang S, Lu Q, Yan JH, Mossman KL, Lin RT, Zheng CF(*). The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway. Plos One, 2013, 8(1), e54586. (SCI, IF=3.534)
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054586

4)    Cai MS, Deng SX, Li ML(*). Comparison of the immune responses in BALB/c Mice following immunization with DNA-based and live attenuated vaccines delivered via different routes. Vaccine, 2013, 31(9),1353-1356. (SCI, IF=3.485)
https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(12)01308-4

5)    Cai MS, Jiang S, Zeng ZC, Li XW, Mo CC, Yang YJ, Chen CK, Xie PP, Bian Y, Wang JL, Huang JL, Chen DX, Peng T, Li ML(*). Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22. Cell & Bioscience, 2016, 6: 3. (SCI, IF=3.294)
https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-016-0069-7

6)    Cai MS, Jiang S, Li XW, Zeng ZC, Li ML(*). Characterization of the nuclear import mechanisms of HSV-1 UL31. Biological Chemistry. 2016, 397(6): 555-561. (SCI, IF=3.273)
https://www.degruyter.com/doi/10.1515/hsz-2015-0299

7)    Cai MS, Huang ZB, Liao ZM, Chen T, Wang P, Jiang S, Chen DX, Peng T, Bian Y, Hong GD, Yang H, Zeng ZC, Li XW, Li ML(*). Characterization of the subcellular localization and nuclear import molecular mechanisms of herpes simplex virus 1 UL2. Biological Chemistry. 2017, 398(4): 509-517. (SCI, IF=3.273)
https://www.degruyter.com/doi/10.1515/hsz-2016-0268 

8)    Cai MS, Li ML, Zheng CF(*). Herpesviral infection and Toll-like receptor 2. Protein & Cell, 2012, 3(8), 590-601. (SCI, IF=3.22)

https://dx.doi.org/10.1007/s13238-012-2059-9

9)    Li ML, Jiang S, Mo CC, Wang JL, Huang JL, Zeng ZC, Li XW, Chen CK, Yang YJ, Peng T, Cai MS(*). Identification of molecular determinants for the nuclear import of pseudorabies virus UL31. Archives of Biochemistry and Biophysics, 2015, 587, 12-7. (SCI, IF=2.807)
https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(15)30075-8

10)    Li ML, Jiang S, Wang JL, Mo CC, Zeng ZC, Yang YJ, Chen CK, Li XW, Cui W, Huang JL, Peng T, Cai MS(*). Characterization of the nuclear import and export signals of pseudorabies virus UL31. Archives of Virology, 2015, 160, 2591-2594. (SCI, IF=2.255)
https://link.springer.com/article/10.1007/s00705-015-2527-7

11)    Cai MS, Chen DX, Zeng ZC, Yang H, Jiang S, Li XW, Mai JY, Peng T, Li ML*. Characterization of the nuclear import signal of herpes simplex virus 1 UL31. Archives of Virology, 2016, 161(9):2379-2385. (SCI, IF=2.058)
https://dx.doi.org/10.1007/s00705-016-2910-z

12)    Li ML, Cui W, Mo CC, Wang JL, Zhao ZY, Cai MS(*). Cloning, expression, purification, antiserum preparation and its characteristics of the truncated UL6 protein of herpes simplex virus 1. Molecular Biology Reports, 2014, 41(9), 5997-6002. (SCI, IF=2.024)
https://dx.doi.org/10.1007/s11033-014-3477-y

2.    Representative papers published at the time of Ph.D. candidate
13)    Cai MS, Wang S, Long J, Zheng CF(*). Probing of the nuclear import and export signals and subcellular transport mechanism of varicella-zoster virus tegument protein open reading frame 10. Medical Microbiology and Immunology, 2012, 201(1), 103-111. (SCI, IF=3.545)
https://link.springer.com/article/10.1007/s00430-011-0211-4

14)    Cai MS, Wang S, Xing JJ, Zheng CF(*). Characterization of the nuclear import and export signals, and subcellular transport mechanism of varicella-zoster virus ORF9. Journal of General Virology, 2011, 92(Pt 3), 621-626. (SCI, IF=3.363)
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.027029-0#tab2

15)    Li ML, Wang S, Cai MS, Zheng CF(*). Identification of nuclear and nucleolar localization signals of PRV early protein UL54 reveals that its nuclear targeting is required for efficient production of virus. Journal of virology, 2011, 85, 10239–10251. (SCI, IF=5.402)
http://jvi.asm.org/content/85/19/10239.long

16)    Wang L, Li ML, Cai MS, Xing JJ, Wang S, Zheng CF(*). A PY-nuclear localization signal is required for nuclear accumulation of HCMV UL79 protein. Medical Microbiology and Immunology, 2012, 201(3),381-387. (SCI, IF=3.545)

https://link.springer.com/article/10.1007/s00430-012-0243-4

17)    Li ML, Wang S, Cai MS, Guo H, Zheng CF(*). Characterization of molecular determinants for nucleocytoplasmic shuttling of PRV UL54. Virology, 2011, 417, 385-417. (SCI, IF=3.351)
https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(11)00268-6

3.    Representative papers published at the time of M.Sc. candidate
18)    Cai MS, Cheng AC(*), Wang MS, Chen WP, Zhang X, Zheng SX, Pu Y, Lou KP, Zhang Y, Sun L, Wang LL, Zhu DK, Luo QH, Chen XY. Characterization of the duck plague virus UL35 gene. Intervirology, 2010, 53(6), 408-416. (SCI, IF=1.756)
https://www.karger.com/?DOI=10.1159/000317291

19)    Cai MS, Cheng AC (*), Wang MS, Zhao LC, Zhu DK, Luo QH, Liu F, Chen XY. His6-tagged UL35 protein of duck plague virus: expression, purification, and production of polyclonal antibody. Intervirology, 2009, 52(3),141-151. (SCI, IF=1.106)
https://www.karger.com/?DOI=10.1159/000221833

20)    Cai MS, Cheng AC (*), Wang MS, Zhao LC, Zhu DK, Luo QH, Liu F, Chen XY. Characterization of synonymous codon usage bias in the duck plague virus UL35 gene. Intervirology, 2009, 52(5), 266-278. (SCI, IF=1.106)
https://www.karger.com/Article/Abstract/231992

Research Interest: Antigen processing and presentation, relating to the understanding of these processes and manipulation of them in order to treat.

Research Interest: Clinical Immunology.

Research Interest: Molecular biology of viruses, the interactions of viruses with host cells, the pathogenesis of viral diseases, the post-translational modification of viral proteins, and mechanisms of host defense. The research works are designed to increase fundamental knowledge as well as to facilitate the development of new approaches to control of viral infection.

Research Interest: Conduct several molecular biology and genomic assays including Sequencing, Cloning, RT-PCR, Southern blot, Northern blot, and Immunostaining.

Research Interest: The structure of sulfated polysaccharides extracts from seaweeds. The activity of sulfated polysaccharides such as nephrophaty and Parkinsion Disease. The comprehensive utilization of seaweeds especially Saccharina japonica.

Since July 2008, assistant in the Department of Epidemiology, MU- Plovdiv

From April 2020 epidemiologist at the Hygiene and Epidemiology Department, University Hospital "St. George" EAD

From September 2022 Acting Head of the Hygiene and Epidemiological Department, University Hospital "St. George" EAD

On 27.12.2020 applied the first vaccine in the history of the vaccination campaign against COVID-19 in Plovdiv

In 2021, she was part of the Ministry of Education and Culture of the Republic of Bulgaria campaign to educate teachers about vaccines against COVID-19.

In 2021-2022 advises on vaccines againstCOVID-19 on the National Patient Helpline toll-free Organization.

2021-2022 cooperates with the foundation "For our children"

2021-2023 participated in expert meetings on epidemiology at the Ministry of Health of the Republic of Bulgaria.

In 2022,  she was part of a working group at the Council of Ministers- Republic of Bulgaria.

Member of:

International epidemiological association (IEA) Bacti Vac Network. Bulgarian Scientific Society for Epidemiology of Infectious and Non-Infectious Diseases Bulgarian Association of Preventive Medicine. The South Bulgarian Society of Infectious Diseases, Epidemiology and Parasitology. Bulgarian Association for Prevention and Infection Control.

Research Interests:

Vaccines, vaccinology, infectious diseases, emerging diseases, epidemics, pandemics, COVID-19, varicella, shingles, measles.

List of Publications:

1. Tomov L, Chervenkov L, Miteva DG, Batselova H, Velikova T. Applications of time series analysis in epidemiology: Literature review and our experience during COVID-19 pandemic. World J Clin Cases. 2023 Oct 16;11(29):6974-6983. doi: 10.12998/wjcc.v11.i29.6974. PMID: 37946767; PMCID: PMC10631421.
   
2. Mileva N, Vasilev GH, Ganev B, Chervenkov L, Batselova H, Tzotcheva I, Tomov L, Velikova T, Lazova S. Cardiovascular Manifestations of Multisystem Inflammatory Syndrome in Children: A Single-Center Bulgarian Study. Medicina (Kaunas). 2023 Dec 14;59(12):2175. doi: 10.3390/medicina59122175. PMID: 38138278; PMCID: PMC10744581.
3. Dimitrov, G., Valkov, T., Batselova, H., Kounchev, O., Momekov, G., Argirova, R. Nationwide analysis of the impact of COVID-19 in patients with a cardiovascular, oncological or chronic pulmonary disease in the context of an Eastern European country with a low vaccination rate, Bulgaria: March 2020-April 2022 (2023) BMJ Open, 13 (8), art. no. e068431,
4. Miteva, D., Kitanova, M., Batselova, H., Lazova, S., Chervenkov, L., Peshevska-Sekulovska, M., Sekulovski, M., Gulinac, M., Vasilev, G.V., Tomov, L., Velikova, T. The End or a New Era of Development of SARS-CoV-2 Virus: Genetic Variants Responsible for Severe COVID-19 and Clinical Efficacy of the Most Commonly Used Vaccines in Clinical Practice (2023) Vaccines, 11 (7), art. no. 1181.
5. Ivanov N, Krastev B, Miteva DG, Batselova H, Alexandrova R, Velikova T. Effectiveness and safety of COVID-19 vaccines in patients with oncological diseases: State-of-the-art. World J Clin Oncol. 2023 Sep 24;14(9):343-356
6. Tomov, L., Batselova, H., Lazova, S., Ganev, B., Tzocheva, I., Velikova, T. Role of children in the Bulgarian COVID-19 epidemic: A mathematical model study (2023) World Journal of Experimental Medicine, 13 (3), pp. 28-46.
7.  Sekulovski, M. Mileva, N. Vasilev, G.V. Miteva, D. Gulinac, M. Peshevska-Sekulovska, M. Chervenkov, L. Batselova, H. Vasilev, G.H.; Tomov, L.; et al. Blood Coagulation and Thrombotic Disorders following SARS-CoV-2 Infection and COVID-19 Vaccination. Biomedicines 2023, 11, 2813.
8. Slabakova, Y.; Gerasoudis, S.; Miteva, D.; Peshevska-Sekulovska, M.; Batselova, H.; Snegarova, V.; Vasilev, G.V.; Vasilev, G.H.; Sekulovski, M.; Lazova, S.; et al. SARS-CoV-2 Variant-Specific Gastrointestinal Symptoms of COVID-19: 2023 Update. Gastroenterol. Insights 2023, 14, 431-445. https://doi.org/10.3390/gastroent14040032 .
9. Tomov, L.P., Batselova, H., Velikova, T.Changes in Patterns of Infectivity and Mortality with SARS-CoV-2 Omicron Variant in Bulgaria.Computer Science and Education in Computer Science. CSECS 2023. Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, vol 514. Springer, Cham. https://doi.org/10.1007/978-3-031-44668-9_15.
10. Tomov, L.P., Batselova, H.M., Velikova, T.V. COVID-19 Delta Wave Caused Early Overburden of Hospital Capacity in the Bulgarian Healthcare System in 2021 (2022) Healthcare (Switzerland), 10 (4), art. no. 600.
11. Tomov, L., Batselova, H., Velikova, T.V. Estimating COVID Case Fatality Rate in Bulgaria for 2020–2021(2022) Lecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering, LNICST, 450 LNICST, pp. 102-115.
12. Snegarova V, Miteva D, Gulinac M, Peshevska-Sekulovska M, Batselova H, Velikova T. COVID-19 inpatients with gastrointestinal stromal tumors: Recommendations for management and vaccination. World J Gastrointest Pathophysiol 2022; 13(5): 170-177
13. Vasilev G, Kabakchieva P, Miteva D, Batselova H, Velikova T. Effectiveness and safety of COVID-19vaccines in patients with diabetes as a factor for vaccine hesitancy. World J Diabetes 2022; 13(9): 738-751.
14. Miteva D, Peshevska-Sekulovska M, Snegarova V, Batselova H, Alexandrova R, Velikova T. Mucosal COVID-19 vaccines: Risks, benefits and control of the pandemic. World J Virol 2022; 11(5): 221-236.
15. Tomov L, Miteva D, Sekulovski M, Batselova H, Velikova T. Pandemic control-do's and don'ts from a control theory perspective. World Journal of Methodology 12.5 (2022): 392.
16. Velikova, T., Kukov, A., Mihova, A., Snegarova, V., Batselova, H., Nakov, R. Gastrointestinal mucosal immunity and covid-19 (2021) World Journal of Gastroenterology, 27 (30), pp. 5047-5059.
17. Tomov, L., Velikova, T., Batselova, H. HEALTH RISK MANAGEMENT IN KINDERGARTENS AND SCHOOLS DURING COVID-19 PANDEMIC (2021) General Medicine, 23 (6), pp. 22-27.
    
18. Velikova, T., Batselova, H., Jenkov, V. IMPACT OF COVID‐19 PANDEMIC ON MENTAL HEALTH: A CROSS‐SECTIONAL SURVEY OF 1,020 BULGARIAN CITIZENS. Bulgarian Journal of Psychiatry (2020), 5 (3) , 10-18.
19. Velikova TV, Kotsev SV, Georgiev DS, Batselova HM. Immunological aspects of COVID-19: What do we know? World J Biol Chem. 2020 Sep 27;11(2):14-29.
20. Бацелова Х., Кеворкян А., Райчева Р., Бойкинова О., Балтаджиев И., Шопова Й., Стоилова Й. Епидемиологично проучване на хоспитализираните пациенти с варицела в Пловдивска област за периода 2000-2011г. Обща медицина, 2013, XV (3).
21. Baltadzhiev, I., Stoilova, J., Popivanova, N., Bazelova, H. Changes in the Viral Hepatitis B (VHB) morbidity 1987-2006 (2009) Problems of Infectious and Parasitic Diseases, 37 (1), pp. 39-40.