Accurate Rickettsia Assays for IgG and IgM Serodiagnosis

Lee Fuller*

It had been recommended in 2020 by the Centers for Disease Control (CDC) that serodiagnosis of acute rickettsiosis specifically utilize the IFA-IgG assay. This was a new and curious requirement for all testing facilities, namely the use of an assay that was neither described in detail nor actually relevant for acute phase diagnosis of a potentially fatal disease. A detailed protocol for this assay should have been included in this announcement to encourage rapid compliance, along with a detailed explanation of the relevance of this specific assay. This was not the case, however, with the result being false-negative IFA-IgG reports over several seasons nationally.

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Published on: Oct 2, 2026 Pages: 4-5

Full Text PDF Full Text HTML DOI: 10.17352/apm.000041
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