The Tudor Sweating Sickness and ME/CFS: A Hypothesis of Pathogenic Evolution and Modern Disease Manifestation

Matthew Kovacs*

This paper presents a novel hypothesis connecting Tudor Sweating Sickness (TSS), which caused five major epidemics in England between 1485 and 1551, with modern Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Through comprehensive analysis of historical records, epidemiological patterns, and clinical presentations, it is proposed that ME/CFS may represent an evolved form of the pathogen responsible for TSS. This analysis reveals striking similarities in demographic distribution, symptom patterns, and physiological mechanisms, suggesting a potential evolutionary link between these conditions.

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Published on: Mar 13, 2025 Pages: 1-9

Full Text PDF Full Text HTML DOI: 10.17352/2455-5363.000063
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