Thiolutin Derivatives as inhibitor of RNA-Dependent RNA Polymerase (RdRP) of Hepatitis C Virus: An In-silico Approach

Muhammad Imran Qadir*, Asma Munawar, Syed Bilal Hussain

Docking study of few Thiolutin derivatives, which originally act as Hepatitis C Virus RNA Dependent RNA Polymerase (RdRP) inhibitor, was performed by using AutoDock Vina. The docking studies reveal that thiolutin interacted with Hepatitis C Virus RNA Dependent RNA Polymerase through hydrogen bonding as well as hydrophobic interactions. Its binding energy after modification (Thiolutin1) was -6.7 kcal/mol, which was greater than the original thiolutin affinity.

Keywords: Thiolutin; Drug design; Hydrogen bonding; Hepatitis C Virus RNA Dependent RNA Polymerase; AutoDock Vina

Published on: Jan 17, 2018 Pages: 1-3

Full Text PDF Full Text HTML DOI: 10.17352/aaa.000003
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